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10-Hydroxy Lycopodium alkaloids
・ 10-Hydroxydecanoic acid
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10-Hydroxy Lycopodium alkaloids : ウィキペディア英語版
10-Hydroxy Lycopodium alkaloids

The 10-hydroxy ''Lycopodium'' alkaloids, 10-hydroxylycopodine, deacetylpaniculine and paniculine, are a series of natural products isolated from a Chilean club moss ''Lycopodium confertum''. Deacetylpaniculine and paniculine were also isolated from ''Lycopodium paniculatum''.
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The ''Lycopodium'' alkaloids are of interest due to their biological activity and unique skeletal characteristics, however, many compounds in this class have not been well studied.
==Synthesis==

The first enantioselective synthesis of 10-hydroxylycopodine, deacetylpaniculine and paniculine was published by Mrinmoy Saha and Professor Rich Carter in 2013 from Oregon State University. A common intermediate strategy was used to accomplish the total syntheses. The key steps toward the syntheses are an organocatalyzed (Proline sulfonamide catalyst nicknamed as Hua Cat.) Michael reaction and a Zn (OTf)2 mediated conformationally accelerated Mannich reaction.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「10-Hydroxy Lycopodium alkaloids」の詳細全文を読む



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