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10-Hydroxy Lycopodium alkaloids : ウィキペディア英語版 | 10-Hydroxy Lycopodium alkaloids
The 10-hydroxy ''Lycopodium'' alkaloids, 10-hydroxylycopodine, deacetylpaniculine and paniculine, are a series of natural products isolated from a Chilean club moss ''Lycopodium confertum''. Deacetylpaniculine and paniculine were also isolated from ''Lycopodium paniculatum''. center The ''Lycopodium'' alkaloids are of interest due to their biological activity and unique skeletal characteristics, however, many compounds in this class have not been well studied. ==Synthesis==
The first enantioselective synthesis of 10-hydroxylycopodine, deacetylpaniculine and paniculine was published by Mrinmoy Saha and Professor Rich Carter in 2013 from Oregon State University. A common intermediate strategy was used to accomplish the total syntheses. The key steps toward the syntheses are an organocatalyzed (Proline sulfonamide catalyst nicknamed as Hua Cat.) Michael reaction and a Zn (OTf)2 mediated conformationally accelerated Mannich reaction.
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